Backbone Motion by Inverse Kinematics for Protein Design
نویسنده
چکیده
The second BioGeometry meeting of 2003 will take place at Duke University on Monday-Tuesday, November 17-18. PIs and students from the four participating institutions will attend, as will a representative from the NSF. Motivation: The problem of protein design is to construct an amino acid sequence that folds to a desired structure. PI Homme Hellinga (Duke Biochem) has had significant success in designing receptor proteins by starting with a given protein, fixing the backbone as a scaffold, and using Dead End Elimination (DEE) to search for changes in the sequence that will create desired structure in the binding pocket. These include changing ribose binding protein to recognize and bind to TNT [1].
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